Mutations in PDE6β gene result in a progressive loss of vision. Describe generation of a potential viral vector for treatment of this disease. What are the advantages and disadvantages of using this viral vector in gene therapy?

Case 10

A 22-year old woman presents    at the walk-in health clinic with slight fever (38.5C), a complaint of frequent    urination, burning on urination, vaginal discharge and a small lesion on the    labia.

The woman reported that    she was moderately sexually active and had three sexual partners in the past    six months. Her last sexual contacts were about 7 days earlier. She had developed    mild symptoms about 5 days earlier, beginning with a discharge from the vagina.    She began having pain on urination about 3 days earlier.

Urine analysis revealed    a pH of 8.2, some white cells and a few red blood cells. There was protein in    the urine. A smear of the vaginal secretion showed a number of Gram-negative    cocci.

1. What is your diagnosis      here?

2. What clinical features      are critical to your diagnosis?

3. What further actions      must be taken?

Theme 2

Mutations in PDE6β gene result in a progressive loss of vision. Describe generation of a potential viral vector for treatment of this disease. What are the advantages and disadvantages of using this viral vector in gene therapy?

Theme 3

Clostridium difficile (C. diff.) is an opportunistic intestinal bacteria causes severe forms of diarrhea and bowel inflammatory disease. Search and discuss the treatment of C. diff. with Bacteriophages. Are there other types of bacterial infections treated with bacteriophages? What is the mode of action of this treatment option and what is the proposed route of delivery?

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